I'd have to say that in my experience, the most consistently accurate, out of the box,.45 has been the sig p220, full size.
48+ Most Accurate 22 Pistol Out Of The Box
Gif. Useless for offhand shooting, there are better guns suited for that so they would easily out shoot these two for that type of shooting. The freedom is scary accurate but is very picky on setup and hold.
Most accurate bolt action 22lr rifle out of the box months ago, i wrote an article entitled the most accurate 22 rifle for the money that utilized quite a bit of data from four different rifles shooting many types of 22 ammunition. How accurate is a.22 revolver? I've owned and shot a countless number of handguns chambering the round.
If you check out the ruger website you can see a somewhat newer version with a target/varmit weight barrel and upgraded trigger.
Guns.com has you covered with a few of our favorite competition pistols. A functional, compact, metal frame.40 that is as accurate as all get out and made in the united states. Glock17 straight out of the box accurate. Now that we have looked at the caliber the most accurate handgun is likely to use, we can look at some handguns that are contenders to be called the most accurate handgun.